CAPGET
Description
Capecitabine is a prodrug which metabolizes in higher concentrations in tumour cells to the active drug 5-Fluorouracil (5-FU). This is because an enzyme, thymidine phosphorylase, required in the last step of conversion to 5-FU is present in higher concentrations in certain cancer cells of breast, colon and rectum. The upregulation of thymidine phosphorylase by docetaxel makes it a synergistic combination with capecitabine. Capecitabine provides a valuable option in patients of metastatic breast cancer who are resisitant to anthracycline and paclitaxel-containing regimens or those for whom anthracyclines are contraindicated.
Indications:
- Metastatic colorectal cancer as 1st line therapy
- Locally advanced or metastatic breast cancer after failure of a taxane and an anthracycline-containing regimen
| Generic Name | Strength | Standard | Type | Packing | Pack Size |
| Capecitabine | 150 mg | IHS | Tablets | Strip | 10 |
| Capecitabine | 500 mg | IHS | Tablets | Strip | 10 |